A crash investigator is at the scene together with local police officers, firefighters and a fire officer.
It follows a crash in the early hours of the morning.
Wiltshire Police said a car had hit a house on the A4 London Road between Derry Hill and Pewsham at around 3am. It burst into flames.
Firefighters, paramedics and police attended the scene. The A4 has been shut in both directions since the crash.
Police have not said how many people were injured in the crash.
A crash investigator at the scene of the crash Pictures: DAVE COX